Phosphotriesterase: an enzyme in search of its natural substrate.

نویسندگان

  • F M Raushel
  • H M Holden
چکیده

The bacterial PTE is able to catalyze the hydrolysis of a wide range of organophosphate nerve agents. The active site has been shown to consist of a unique binuclear metal center that has evolved to deliver hydroxide to the site of bond cleavage. The reaction rate for the hydrolysis of activated substrates such as paraoxon is limited by product release or an associated protein conformational change.

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عنوان ژورنال:
  • Advances in enzymology and related areas of molecular biology

دوره 74  شماره 

صفحات  -

تاریخ انتشار 2000